In a genetic mouse model of nephrotic syndrome caused by inducible deletion of podocin (Nphs2Δipod), nephrotic mice lacking Plg (Nphs2Δipod *Plg−/−) developed the same degree of proteinuria as Nphs2Δipod *Plg+/+ mice (Xiao et al., 2021). Here, PLG is linked to nephrotic syndrome.