However, the amount of OVA-specific IgE (Figure 1F), IL-5 (Figure 1G), and IL-13 (Figure 1H) in BALF obtained from macrophage-Arf6 cKO mice decreased compared with that obtained from WT mice, suggesting that macrophages exacerbate asthma-like allergic inflammation through Arf6. The gene discussed is IGHE; the disease is asthma.