In contrast, DKO Ifnar1-/-;Ifngr1-/- C57BL/6J mice developed delimited skin lesions measuring >1 cm in diameter that were necrotic, hardened, non-pruritic, and surrounded by an indurated red halo (Figure 1b), similar to human eschars (Figure 1c; Paddock et al., 2008; Paddock et al., 2004; Kaskas, 2014; Cragun et al., 2010; Herrick et al., 2016). This evidence concerns the gene IFNAR1 and neoplasm.