MIR146B and obesity due to melanocortin 4 receptor deficiency: For Mir146b, prior works have demonstrated decreased expression in obesity and the progression and metastases of cancers including T-cell acute lymphoblastic leukemia and glioblastoma multiforme, and its expression has been noted to decrease with age in the lungs in human bronchial biopsies from healthy individuals (Hulsmans et al., 2012; Correia et al., 2016; Li et al., 2013; Ong et al., 2019).