The PeFAUcn3 to LS projections also led to sustained reductions in pup interactions, a finding that is consistent with a recent study showing that LS neurons expressing corticotrophin-releasing factor receptor 2 (CRFR2), the high-affinity receptor for Ucn3, may control persistent anxiety behavior (Anthony et al., 2014) and, in addition, led to incidences of pup-directed aggression. The gene discussed is UCN3; the disease is Anxiety.