further observed that postinfluenza Spn secondary infection induce the suppression and reducing of B lymphocyte compared with influenza A virus infection alone.[46] In short, we thought that the increase of Spn after SARS‐CoV‐2 infection may promote COVID‐19 development through suppressing lymphocyte, which attributed to favorable conditions for Spn colonization and multiplication provided by SARS‐CoV‐2 infection. This evidence concerns the gene SPN and COVID-19.