Previously, Chen et al.29reported that, examined by IHC, positive PD‐L1 expression in primary cancer cells was found in 136 (65.3%) patients, which were negatively correlated with lymph node metastasis, which is similar to the study by Velcheti et al.30In the present study, the OS as well as MST in the TOPN positive group was significantly lower than those in the TOPN negative group, and DFS in the TOPN positive group was significantly longer than that in TOPN negative group, suggesting that TOPN is a prognosis biomarker independent of PD‐L1. Here, CD274 is linked to cancer.