The demasculinising and depressogenic effects of finasteride raise significant concerns about its application as a therapy in children, particularly given consideration of the high comorbidity of depression and anxiety in TD patients; however, our recent data on isoallopregnanolone as a potential therapy with similar effectiveness as finasteride172 in mouse models of TD highlight that this endogenous AP antagonist (or other compounds with a similar mechanism of action) may be a promising therapeutic alternative for TD, given its optimal profile of clinical tolerability and safety.186. This evidence concerns the gene DHCR7-DT and thanatophoric dysplasia.