Finally, using a mechanically‐loaded acute tendon injury rat model to mimic the profile of tendinopathy, including calcification, we demonstrated the efficacy electromechanical stimulation (EMS) in modulating the expression of ion channels (TRPA1, PIEZO1/2, and KCNK2/4) and in regulating perturbed regenerative processes associated with excessive activation of the BMP signaling. The gene discussed is TRPA1; the disease is disease of the tendon.