RRM2 and hepatocellular carcinoma: To better understand the correlation between these overlapped genes and prognostic significance of HCC patients, we utilized univariate Cox regression analysis to screen out 7 rate‐limiting enzymes with a significant overall prognosis (RRM1, SQLE, PCK1, G6PD, RRM2, UCK2 and IMPDH1) (Figure 2B).