RRM1 and liver cancer: To detect the expression of RRM1, UCK2 and G6PD in RNA‐seq data from HCC animal model, we first detect their expression in the mouse liver cancer tissues and paired normal tissues, and the results showed that the mRNA and protein levels of RRM1, UCK2 and G6PD were significantly higher in tumour tissues compared with those in normal tissues by qRT‐PCR and Western blotting assays (Figure 3A‐B).