Intriguingly, by conjointly analysing the differentially expressed metabolic rate‐limiting enzymes from RNA‐seq data of HCC animal model and TCGA data, 12 transcripts were overlapped (RRM1, SQLE, PCK1, PYGB, G6PD, PLAT, ACSL1, RRM2, UCK2, ASS1, FBP1 and IMPDH1) (Figure 2A). Here, G6PD is linked to hepatocellular carcinoma.