FKBP5 and major depressive disorder: Klengel et al. (2013) found that FKBP5 mediated the interaction of genetic and environmental effects on stress-related psychiatric disorders in adulthood by DNA methylation in functional glucocorticoid-response elements of FKBP5. Weder et al. (2014) found differences in FKBP5 methylation between children exposed and non-exposed to maltreatment in relation to depression.