TP53 and PPM1D are found in only 3% and 5% (Supplemental Digital Table 2; http://links.lww.com/HS/A189).7,26 In cancer patients, PPM1D and TP53 CHIP mutations are overrepresented,6,25,31 especially due to exposure to both chemotherapy and radiotherapy. This evidence concerns the gene PPM1D and cancer.