In multivariate analysis, baseline parameters influencing OS were age at TRMN (HR = 1.03 [95% CI, 1–1.06], P = 0.03), performance status (HR = 3.75 [95% CI, 2.04–6.91], P < 0.001) and Lindsley’s modified genetic classifier (“TP53/PPM1D” versus “MDS-like” [HR = 0.51 (0.25–1.06), P = 0.1, versus “de novo/pan-AML” [HR = 0.41 (95% CI, 0.2–0.82)], P = 0.012) (Table 3). The gene discussed is TP53; the disease is acute myeloid leukemia.