LRP1 knockout has been found to be associated with increased intestinal inflammation in animal model,4 and LCN2-deficient mice are more prone to bacterial infection.5 On the other hand, higher expression of LCN2 has been reported in various inflammatory conditions.6 Hence, it is necessary to explore the relation of LCN2 and LRP1 with intestinal inflammation in the context of EED. This evidence concerns the gene LCN2 and bacterial infectious disease.