LAMB2 and telomere syndrome: While three of those OSCTs had RNA expression levels of SOX10 above the cutoff and immunohistochemically labeled for SOX-10, one OSCT also had RNA expression levels for DES above the cutoff, and all four OSCTs were immunohistochemically positive for laminin and negative for MDX and did not express TYR RNA, making a diagnosis of STS more likely.