In terms of inflammatory diseases, the expression of miR-205-5b in the serum of LPS-induced sepsis mice (52) was significantly down-regulated, which could inhibit nuclear factor kappa B (NF-κB) signaling, apoptosis and production of proinflammatory factors by targeting high mobility group box protein 1 (HMGB1) and leading to the continuous proliferation of human pulmonary alveolar epithelial cells (53). This evidence concerns the gene NFKB1 and Sepsis.