In addition, human miR-143 can inhibit breast cancer cell proliferation and metastasis by regulating the gene expression of MAPK3 (45), MAPK7 (46), MYBL2 (47), CD44 (48), and ERBB1 (49) in cooperation with protein levels and phosphorylation status of AKT, Wnt/β-catenin, SAPK/JNK, and FAK of NF-κB signaling pathways and multiple oncoproteins in JAK/STAT signaling pathway (50). This evidence concerns the gene AKT1 and breast carcinoma.