FMO5 and atherosclerosis: We hypothesized that in vivo inhibition of Rac1 GTPase results in reduced NADPH oxidase activity and thus diminished ROS production in the arterial wall, and that chronic Rac1 inhibition in a mouse model of atherosclerosis will improve endothelial function and reduce atherosclerosis development and macrophage infiltration in atherosclerotic lesions.