In addition elevated plasma IL-37 has been detected in acute ischemic stroke patients, and IL-37 is an independent association with poorer prognoses (80), which is consistent with others, showing elevated circulating IL-37 is associated with a poor outcome in ST-segment elevation acute myocardial infarction in acute coronary syndrome patients (81, 82), although this finding remains controversial (83). Here, IL37 is linked to myocardial infarction.