CUX1 and cancer: As a major member of the CUX family, it is involved in multiple biological processes including cell differentiation, proliferation, cell cycle regulation, tissue development, and double strand breaks (DSBs) repair response, besides, CUX1 expression was abnormally elevated in many malignant tumors and was implicated in tumorigenesis (Ramdzan and Nepveu, 2014; Wong et al., 2014; Jo et al., 2017).