Our study collected and extracted data of clinical indicators and gene expression of gliomas from Chinese Glioma Genome Atlas (CGGA), The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) databases and clinical samples, gradually analyzed the influence of PACSIN1 expression on the related clinical indicators of gliomas, studied its clinical significance and explored the mechanism of PACSIN1 affecting gliomas, so as to provide the experimental basis for the diagnosis, prognosis, development and treatment of gliomas. Here, PACSIN1 is linked to central nervous system cancer.