It is demonstrated that abnormal activation of the hedgehog (Hh) signaling pathway may be involved in inducing EMT in gastric cancer.And the levels of the Hh pathway marker Gli-1 were associated with levels of the Snail and E-cadherin.All three markers were related to depth of invasion, lymph node metastasis, and pTNM stage in gastric cancer (Wang et al., 2014). The gene discussed is GLI1; the disease is gastric cancer.