CDH1 and gastric cancer: This paper aims to summarize the relationship between E-cadherin and the tumorigenesis, development, metastasis and drug resistance of gastric cancer from the aspects of biological function, inactivation mechanism and clinical significance, discussing the clinical application of E-cadherin in the early diagnosis, prognosis, and therapy of gastric cancer as well as development status of E-cadherin activator, which could provide new ideas for precise therapy of gastric cancer.