For example, in gastric cancer, the MMP1 and MMP2 increased expression is related to the loss of E-cadherin expression, thereby, leading cancer proferliation and metastasis (Zhou et al., 2010).MMP-3 and MMP-7 have association with the development of Helicobacter pylori-related gastric cancer (Yang et al., 2018). This evidence concerns the gene CDH1 and cancer.