In multivariate analysis, male sex (HR: 1.888; 95% CI: 1.267–2.814), age (HR: 1.054; 95% CI: 1.037–1.072), DM (HR: 2.235; 95% CI: 1.416–3.529), ALT (HR: 0.996; 95% CI: 0.991–1.000), total bilirubin (HR: 2.235; 95% CI: 1.416–3.529), and platelet count (HR: 0.995; 95% CI: 0.991–1.000) were the independent predictors for HCC development. The gene discussed is GPT; the disease is hepatocellular carcinoma.