HHV-6 reactivation in ME/CFS patients can also lead to mitochondrial fragmentation and severely compromised energy metabolism (54); this may be linked to reported interactions between the HHV-6B U95 early viral protein and the mitochondrial GRIM-19 protein (55) that results in reduced mitochondrial membrane potential and pronounced mitochondrial impairment. Here, NDUFA13 is linked to myalgic encephalomeyelitis/chronic fatigue syndrome.