GATA2 and acute myeloid leukemia: In contrast, chromosomal inversion and translocation in chromosome 3 at two different breakpoints, tethering the enhancer of GATA2 in the same TAD as EVI1, activate expression of EVI1 and downregulate GATA2, resulting in the development of acute myeloid leukemia (Gröschel et al., 2014).