RELA and neoplasm: In addition, in the nucleus, HMGB1 protein interacts with tumor suppressors, such as p53 (Jayaraman et al., 1998; Rowell et al., 2012), members of the REL transcription factor family (RELA/P65, c-REL, RELB, P50/NF-κB1, and p52/NF-B2 (Agresti et al., 2003), and cyclin-dependent kinases like CDK2 (Neganova et al., 2011).