ZDHHC4 and lung cancer: For LUAD (Figure 9A) and LUSC (Figure 9B) patients, six hub genes, B cell, and DC1 were significantly positively related to stromal score, immune score, and ESTIMATE score, whereas they were negatively associated with tumor purity, which indicated that lung cancer tissues with high expression of hub genes and abundance of B cell and DC1 were more like “hot tumors,” with lower tumor purity and might benefit more from ICB treatment.