LOX and Alzheimer disease: Noticeably, lipoxygenase (LOX), cyclooxygenases (COXs), and cytochrome p450 (CYPs), three well-defined classes of lipid oxidation enzymes which catalyze the deoxygenation of PUFAs, have been reported were changed in AD pathology (Shintoku et al., 2017; Wu et al., 2018).