Besides the perturbed iron export, the expression levels of divalent metal transporter 1 (Dmt1), the main transporter of divalent metal ions which is colocalized with the Aβ in AD pathology, were significantly increased in the AD transgenic model and aged murine model (Xian-hui et al., 2015; Tian et al., 2018). This evidence concerns the gene SLC11A2 and Alzheimer disease.