Ferroptosis in AD has been extensively studied in the past decades and there are multiple signaling pathways were reported in the regulation of ferroptotic cell death in AD, such as the perturbed iron export and transport in iron metabolism pathway, the reduced GSH and Gpx4 levels in redox homeostasis pathway, the accumulated lipid peroxidation and ROS generation in lipid metabolism pathway and some other potential signaling pathways, as summarized in Figure 2. This evidence concerns the gene GPX4 and Alzheimer disease.