14 of the 19 significantly down-regulated GO terms in Hif2a-KD cells were found to overlap with the up-regulated GO gene sets (t-test: P < 0.05) in PAH patients compared to controls, which was statistically significant (cumulative hypergeometric test: P = 9.4 × 10–4). Here, EPAS1 is linked to pulmonary arterial hypertension.