13 of the 19 significantly down-regulated GO terms in Hif2a-KD cells were found to overlap with the up-regulated GO gene sets (t-test: P < 0.05) in PAH patients vs. controls, which was statistically significant (cumulative hypergeometric test: P = 7.3 × 10–7). The gene discussed is EPAS1; the disease is pulmonary arterial hypertension.