CS and Meester-Loeys syndrome: Defects in the core proteins of CS/DSPGs or mutations in CS/DS glycosyltransferases, epimerases, and sulfotransferases lead to a number of diseases, including congenital corneal stromal dystrophy, Meester-Loeys syndrome, and connective tissue diseases (Mizumoto et al., 2017; Kosho et al., 2019; Lautrup et al., 2020).