To ascertain whether the above m6A regulators influenced the disease progression of IBD, we evaluated the mRNA expression of m6A regulators in UC, CD, and normal tissues and found that expression of “readers” (i.e., IGF2BP1 and IGF2BP2) was dramatically decreased in CD tissues compared with normal tissues (P < 0.01) (Figure 1D). This evidence concerns the gene IGF2BP2 and inflammatory bowel disease.