Indeed, in adult T cell leukemia (ATL), the HTLV-1 TAX transcription factor epigenetically upregulates Ellis Van Creveld (EVC) family members, EVC1 and EVC2, both of which have been associated with the cellular HH activity and thus provides the pro-survival attributes of ATL cells (Takahashi et al., 2014). Here, EVC is linked to adult T-cell leukemia/lymphoma.