It can be seen from Figures 1, 2 that compared with the normal breast cancer cells, the expression of E-cadherin protein in the lncRNA TPA overexpression cells was significantly reduced (p < 0.01), and the protein expression of Vimentin, fibronectin and TGF-β1 were significantly increased (p < 0.01). The gene discussed is FN1; the disease is breast cancer.