Furthermore, the present study showed a positive correlation between macrophage M2 and CD8 T cells (p = 0.22), which is contradictory with previous evidence showing that macrophage M2-like TAMs can suppress the recruitment and function of CD8 + T cell, thereby favoring tumor immune escape and driving tumor progression (Dannenmann et al., 2013; Peranzoni et al., 2018; Quaranta and Schmid, 2019). This evidence concerns the gene CD8A and neoplasm.