The transduction of Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling can lead to the production of the protumor cytokines [e.g., IL-1, IL-17, IL-10, TGF-β, vascular endothelial growth factor (VEGF)], which can promote tumor immunogenicity and inhibit the antitumor immune response (Owen et al., 2019). This evidence concerns the gene VEGFA and neoplasm.