Toll-like receptor 3 (TLR3) stimulation of oral cancer cells can cause tumor progression (Urban-Wojciuk et al., 2019), which is evidenced by the fact that the stimulation of TLR3-expressing oral cancer cells lines (buccal OC2 cancer cells) was found to lead to tumor progression via the production of immunosuppressive factors (Chuang et al., 2012). This evidence concerns the gene TLR3 and cancer.