CXCL8 and neoplasm: The overexpression of C-X-C motif chemokine ligand 8 (CXCL8, also called IL-8) in OSCC has been related to poor prognostic outcome due to its promoting effect on the generation and infiltration of CD163-positive M2 type tumor-associated macrophages, which can support and exacerbate the immunosuppression by tumor-infiltrating T cells (Hosono et al., 2017).