WNK2 and colon adenocarcinoma: Aberrant activation of distinct signaling pathways, including the notch signaling pathway, mitogen-activated protein kinase signaling pathway, regulation of actin cytoskeleton, phosphatidylinositol, and the transforming growth factor-beta signaling pathway, among the high-risk score patients is associated with poor prognosis of COAD (Meng et al., 2009; Lähde et al., 2020).