Similarly, immunohistochemistry (IHC) staining of colon cancer tissue with antibodies to P4HA1, STC2, CHPF2, PMM2, PGM2, ENO3, PPARGC1A, and PPP2CB had higher expression of the P4HA1, STC2, PMM2, CHPF2, and ENO3 GRGs in COAD tissue and lower expression of the PPP2CB, PPARGC1A, and PGM2 GRGs in the same tissues (Figures 10B,C). Here, PPARGC1A is linked to malignant colon neoplasm.