FIS1 and gastric cancer: Marzetti et al. (2017) noticed that Fis1 transcription was significantly increased in elderly patients with gastric cancer cachexia. This also appeared in the study from de Castro et al. (2019). Mitochondrial fission is an important mechanism to ensure natural operation by transferring dysfunctional mitochondria to mitophagy (Twig et al., 2008; Dagda et al., 2009).