GSEA enrichment results indicated the underlying mechanism of risk signature on HCC tumorigenesis and development through mTOR (Mossmann et al., 2018), p53 (Meng et al., 2014; Kong et al., 2017), Wnt (Dai et al., 2019; Hu et al., 2019; Huynh et al., 2019; Li et al., 2019; Tan et al., 2019), and MAPK (Drosten and Barbacid, 2020) signal pathways, among others. This evidence concerns the gene TP53 and hepatocellular carcinoma.