PD-L1 positivity is correlated with lower overall survival in anaplastic thyroid cancer (Chintakuntlawar et al., 2017) and worse clinicopathologic characteristics in PTC including reduced progression-free survival, increased lymphovascular invasion, tumor size, and TNM stage (Chowdhury et al., 2016; Shi et al., 2017; Gillanders and O’Neill, 2018). The gene discussed is CD274; the disease is thyroid gland undifferentiated (anaplastic) carcinoma.