ANXA1 is differentially expressed in a variety of tumors and a number of genome-sequencing studies have shown that ANXA1 is highly expressed in gliomas (Ruano et al., 2008; Naryzhnyi et al., 2014; Mallawaaratchy et al., 2015; Qiu et al., 2020), but intensive research on ANXA1 function in glioma was lacking. The gene discussed is ANXA1; the disease is central nervous system cancer.