Other interesting functional variants are present in the CDKN2A and CDKN2B-containing region on chromosome 9, which is frequently altered in many different ALL subtypes (Morison et al., 2002; Mullighan et al., 2007; Safavi et al., 2013; Xu et al., 2015; Hungate et al., 2016; Lundin et al., 2016). This evidence concerns the gene CDKN2A and acute lymphoblastic leukemia.