AURKB and acute lymphoblastic leukemia: With regard to the potential contribution of condensin complex and spindle assembly checkpoint impairments, Molina et al. found that inhibition of the Aurora B kinase and the spindle assembly checkpoint produced substantial chromosomal instability in healthy CD34-positive hematopoietic cells, the outcome of which were indeed aneuploid cells with chromosomes that displayed ALL-typical structural and condensation defects (Molina et al., 2020).