In addition to the conventional therapy options, there is a range of novel potential breakthrough therapies for NB among which are retinoic acid, targeted metaiodobenzylguanidine (MIBG) radiotherapy, antiangiogenic agents, and programmed cell-death 1/programmed cell-death 1 ligand (PD1/PDL1) inhibitors. The gene discussed is PDCD1; the disease is neuroblastoma.