The top 15 pathways identified by STRING in which these proteins play crucial roles include (1) EGFR tyrosine kinase inhibitor resistance, (2) central carbon metabolism in cancer, (3) glioma, (4) melanoma, (5) endometrial cancer, (6) VEGF signaling pathway, (7) bladder cancer, (8) colorectal cancer, (9) non-small-cell lung cancer, (10) platinum drug resistance, (11) prostate cancer, (12) choline metabolism in cancer, (13) pancreatic cancer, (14) ErbB signaling pathway, and (15) gap junctions (Table 1). The gene discussed is EGFR; the disease is melanoma.