Moreover, MYCN and EGFR amplification, PDGFR activation, resistance to TRAIL-induced apoptosis, epigenetic oncogenic deregulation, and increased expression of stem-cell maintenance markers are features shared by both the intracranial brain tumors such as medulloblastoma and the extracranial peripheral nervous system tumor, neuroblastoma. This evidence concerns the gene TNFSF10 and brain neoplasm.