HMGA1 and hereditary clear cell renal cell carcinoma: Interestingly, HMGA1 expression becomes upregulated in a vast majority of tumors such as glioblastomas (36), neuroblastomas (37), and many other solid tumors, including breast (38), pancreatic (39), cervical (40), thyroid (41), prostate (42), colon (43), and renal cell carcinoma (44) and has been highly affiliated with poor prognosis and tumor metastasis (45).