CASP8 and neuroblastoma: NMYC amplification in NB has been implicated in resistance to apoptotic pathways (56, 57) including resistant to TRAIL-induced apoptosis (58) where previous studies have demonstrated the synergistic proapoptotic effect of combined TRAIL treatment in MYCN-negative neuroblastoma cells expressing caspase-8 following IFN-γ treatment (58).