We found that the production of the inflammatory factors IL-1β, IL-6, IL-8, TNF-α and IL-10 in NEC mice was twice, 2.98 times, 1.67 times, 1.88 times and 0.57 times that in NA mice, respectively, and the differences were statistically significant (P<0.05). The gene discussed is IL1B; the disease is necrotizing enterocolitis.