Clinically, we observed that with higher soluble levels of galectin-3 in their cervicovaginal secretions women had significantly lower OR of having incident TV when having normal Nugent score (OR = 0.03, 95% CI = 0, 0.36) or co-infection with HIV (OR 0.39, 95% CI = 0.16–0.96) or HSV (OR = 0.22, 95% CI = 0.06–0.74) (Figure 1). The gene discussed is LGALS3; the disease is coinfection.