LGR5 and colorectal cancer: A similar effect has been observed in colorectal cancer cells, in which BCL3 acts as a co-activator of β-catenin/TCF-mediated transcriptional activity and induces the expression of stemness markers such as LGR5 (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5) and ASCL2 (Achaete-Scute Family BHLH Transcription Factor 2) (28).