KLRK1 and neoplasm: Administration of lymphodepleting chemotherapy and radiation before the infusion of CAR-NK cells could reduce the tumor burden and increase the effector-to-target ratio after transfusion of CAR-NK cells (46).Additionally, radiotherapy-related DNA damage may induce the expression of NKG2D ligands on tumor cells and enhance the cytotoxicity of CAR-NK cells against tumor cells (127).