Herein, the functional role of ARTN in CRC progression has been determined and demonstrated that ARTN promotes progression of CRC by p44/42 MAPK dependent expression of CADHERIN 2 (CDH2, also known as N-CADHERIN) which promotes epithelial-to-mesyenchymal transition and cancer cell metastasis (47). This evidence concerns the gene ARTN and colorectal carcinoma.