AFP and neoplasm: The Cox proportional hazards regression model indicated that RS can significantly improve the prognosis of HAL patients (<i>p</i> = 0.011), although the location and size of tumor as well as the serum AFP value before treatment had no significant effect on their prognosis (<i>p</i> = 0.82, <i>p</i> = 0.96, <i>p</i> = 0.25).<h4>Conclusions</h4>HAL patients have a poor prognosis, and the survival benefits for patients receiving chemoradiotherapy or chemotherapy alone appear to be limited.