To investigate whether OR7E156P participates in the functions of HIF1A on glioma cell aggressiveness, next, U251-MG and U87-MG cells were transduced Lsh-OR7E156P or Lsh-NC, exposed to 1% O2 or 20% O2, and examined cell invasion and DNA synthesis capacity. The gene discussed is HIF1A; the disease is glioma.