TLRs play a crucial role in the activation of innate immunity, promoting cancer progression; therefore, their activation induces genes that encode for numerous inflammatory cytokines, such as tumor necrosis factor-α (TNF- α), INF-1, IL-6, IL-1, granulocyte-colony stimulating factor and different chemokines, including CCL2 and CXCL10 (54, 55). This evidence concerns the gene TNF and cancer.