IFNG (interferon gamma, INFγ)released from CD8+ T cells downregulates the expression of SLC3A2 and SLC7A11, two subunits of the glutamate-cystine antiporter system xc-, inhibits the uptake of cystine by tumor cells, and consequently promotes tumor cell lipid peroxidation and ferroptosis (31). This evidence concerns the gene CD8A and neoplasm.