HEXA and central nervous system cancer: Although according to the survival analysis based on CGGA database, no correlation was observed between HEXA and HEXB mRNA expression and the survival probability in grade II and III gliomas (Figures 5A–D), the survival probability of GBM patients with higher expression of HEXA and HEXB mRNA was significantly shorter (Figures 5E, F), suggesting that HEXA and HEXB expression might act as a prognostic marker in grade IV patients.