As shown in Table 2, the result suggested that the high expression of CD86 was significantly correlated to nine KEGG signaling pathways, including systemic lupus erythematosus, cytokine-cytokine receptor interaction, cell adhesion molecules (CAMs), toll-like receptor signaling pathway, chemokine signaling pathway, natural killer cell-mediated cytotoxicity, T-cell receptor signaling pathway, focal adhesion, and leukocyte transendothelial migration. This evidence concerns the gene CD86 and systemic lupus erythematosus.